"from the box (jar), sent by the gods to Pandora, which she was forbidden to open and which loosed a swarm of evils upon mankind when she opened it out of curiosity: a prolific source of troubles."  Merriam-Webster's Dictionary  If the box is closed it is done so only to prevent hope from escaping.

What the woman (Eve) did in the Garden in Eden, the praxis of the dialectical process—self-justification (rationalization i.e. choosing an open ended and non-directed way of thinking; Rogerian Psychology) that eating of the Tree of the Knowledge of Good and Evil would satisfy her hearts desire (resolution of a self-environmental relationship rift i.e. physiological, self-esteem, and self-actualization; Maslow hierarchy of "felt" needs), Adam harkening to her voice, also imbibed—was a Pandora's Box moment which "loosed a swarm of evils upon mankind."